Computational Systems Biology

Computational Systems Biology Group (CNB-CSIC)

Welcome to the web space of the Computational Systems Biology Group. We are integrated in the Systems Biology Program of the National Centre for Biotechnology (CNB-CSIC).

Use the links above to access the different sections.

Prediction of functional residues in proteins

ODCs - Connections between rare diseases through shared genes and protein interactions

Effect of predicted accessibility on mirrortree

Biological significance of GeneOntology biological processes

Functional interpretation of metabolomics data

Sequence determinants of ATP hydrolysis asymmetry in the CCT chaperonins

Rational design of a Jasmonate antagonist

Functional annotation at the domain level

SNP-based characterization of mouse strains

Vectorial representation of chemical compounds and metabolic reactions

Extraction of metabolite co-dependencies from metabonomics data

Prediction of chemical compound biodegradability

Phylogeny-independent prediction of functional residues

Co-evolutionary analysis of protein multiple sequence alignments

Determinants of the amino-acid racemases substrate specificity

Relationship between protein functional features and mRNA local translation speed

Global analysis of protein disorder in A. thaliana

Mirrortree - Co-evolution-based prediction of protein interactions

Prediction of protein interaction partners using physical docking

Detection of significant protein co-evolution

Events/News

Biology Methods and Protocols (BIOMAP) A new journal from Oxford University Press for publishing methodology and protocol papers in all areas of Biological Sciences, including Bioinformatics.

Last updates and changes

[NEW]	ODCs server - Connections between rare diseases through shared genes and protein interactions
[NEW]	MBROLE 2.0 server - Functional analysis of metabolomics data. New chemical and biological databases added, together with improved functionalities and interface
[NEW]	Breaking-Cas server - gRNA design for CRISPR/Cas experiments for the ~700 eucaryotic genomes available in ENSEMBL through an interactive web interface. @BioinfoGP
	Review on Practical analysis of specificity-determining residues in protein families. Brief Bioinform. (2016) 17(2):255-61.